Constitutive Somatostatin Receptor Subtype 2 Activity Attenuates GH Synthesis
نویسندگان
چکیده
منابع مشابه
Constitutive Somatostatin Receptor Subtype-3 Signaling Suppresses Growth Hormone Synthesis
Somatostatin signals through somatostatin receptor subtypes (SSTR) 2 and 5 to attenuate GH secretion. Although expressed in normal pituitary glands and in GH-secreting pituitary tumors, SSTR3 function was unclear, and we have now determined the role of SSTR3 in somatotroph function. Stable rat pituitary tumor cell (GC) transfectants of human SSTR3 (GpSSTR3(WT)) showed suppression of rat (r) GH ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2013
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2013-1132